MHMs Menopause Blog

Effect Of Combined HRT On Breast Cancer Risk

September 18, 2016 | By Julieann Roberts, Editor.

A Breast Cancer Now Study finds the effect of Combined HRT on breast cancer risk is likely to have been underestimated.

The effect of combined hormone replacement therapy (HRT) in increasing a woman’s risk of breast cancer is likely to have been underestimated by a number of previous studies, according to a new prospective study published in the British Journal of Cancer, highlighted on the British Menopause Society Website on 23 August 2016.

  • Women taking combined HRT are 2.7 times more likely to develop breast cancer than non-users, with risk increasing with longer HRT use, Breast Cancer Now Generations Study finds
  • Study comprehensively updated information about women’s HRT use and analysed accurately to allow for age at menopause
  • Research suggests many previous investigations which did not do so may have underestimated the increased risk of breast cancer by up to 60%

The new research was part of the Breast Cancer Now Generations Study – a major prospective study led by scientists at The Institute of Cancer Research, London, following more than 100,000 women for 40 years to investigate the causes of breast cancer.

Some 39,000 women with a known age at menopause were identified and monitored for six years, with follow-up questionnaires gathering comprehensive data on any HRT use (type and duration) as well as their general health and lifestyle.

During this time, 775 of these women developed breast cancer, with the researchers finding that women using combined HRT (for a median duration of 5.4 years) were 2.7 times more likely to develop breast cancer during the period of HRT use than women who had never used HRT.

You can read the British Menopause Society’s response to this study here.

Sources:

Breast Cancer Now study finds the effect of combined HRT on breast cancer risk is likely to have been underestimated. Retrieved from https://thebms.org.uk/2016/08/breast-cancer-now-study-finds-effect-combined-hrt-breast-cancer-risk-likely-underestimated/

BMS/RCOG response to Breast Cancer Now Generations Study on HRT use and breast cancer risk. Retrieved from https://thebms.org.uk/2016/08/bmsrcog-response-breast-cancer-now-generations-study-hrt-use-breast-cancer-risk/

 

 

 

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